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Scientists Create Dopamine-Brain Model

Through interdisciplinary collaboration, researchers at the University of Copenhagen have created a model of the way the brain releases dopamine. This model will be an important tool in helping scientists better understand how humans learn and how the brain perceives reward. Because of dopamine’s involvement in these activities, the researchers hope that the model can assist in further understanding drug and alcohol addiction and necessary treatment and rehabilitation options.

Dopamine is involved in a number of the brain’s processes that control the way we behave. It plays an important role plays in our ability to handle stress, be motivated, and create an overall sense of well-being. It is a key neurotransmitter in the reward center of the brain.

Certain actions that exceed expectation will cause the brain to temporarily release more dopamine. Actions that are worse than expected will cause the brain to momentarily stop releasing dopamine. This ultimately makes dopamine a “learning signal” that causes us to repeat the actions that give us higher levels of dopamine and avoid those that result in lower dopamine levels. This action also applies to food, sex and competition. The use of drugs and alcohol also raises the level of dopamine.

Some scientists have argued that the dopamine system doesn’t react quick enough to be a part of the human learning process. However, they focused primarily on the slow feedback time when experiencing something negative. Whereas, this new model shows that “the collective signal from many cells provides a rapid enough reaction to influence learning.” (Medical News Today)

The new dopamine model was created in a collaborative effort among physicists, mathematicians and neurobiologists, and its predictions are supported by observations made in animal models. The researches are hoping that it will help overcome some of the challenges faced by neurologists that are often unable to study active brains in living humans. Once the researches are certain the model is correct, then they will begin applying it to dopamine-related illness such as drug and alcohol addiction.

The researchers’ dopamine model will soon be described in the cover article of Journal of Neuroscience.

Why Men Are Often More Susceptible to Alcoholism

Studies show that men are twice as likely to develop alcoholism than women; however, the underlying biological factors contributing to this difference has been, for the most part, unclear. A new study published in Biological Psychiatry, points to dopamine being an important factor in this difference.

Dopamine is a key neurotransmitter in the reward center of the brain that plays an important role in our ability to handle stress, be motivated, and create an overall sense of well-being. The use of drugs or alcohol raises the level of dopamine and confuses the brain into thinking that the action was positive and should be repeated.

Researchers from Columbia and Yale University studied alcohol consumption amongst male and female social drinkers. After consuming alcoholic or non-alcoholic drinks, each participant underwent a PET scan that measured the amount of alcohol-induced dopamine released.

Despite similar consumption of alcohol, the study found men to have greater amounts of dopamine released than the women. The increase was found in an area of the brain (ventral striatum) strongly associated with pleasure, reinforcement and addiction. Because of the increased release of dopamine, men had a stronger positive association with the effects of alcohol intoxication. This initial positive reinforcement may contribute to the risk for habit formation.

The study also found that episodes of repeated heavy drinking resulted in a decline in alcohol-induced dopamine release. This observation supports one of the hallmarks of developing tolerance or transitioning into a more chronic dependence on alcohol.

Understanding Impulse and Neurological Involvement: Addiction Insight

A recent study published in the Journal of Neuroscience found how a rat brain triggers and suppresses impulsive behavior. Canadian researchers hope that this will lead to new methods for diagnosing and treating addiction in humans.

How the brain deals with impulse control, or poor impulse control, is known to be involved in a number of complex mental health problems including addiction. In order to understand how the brain mediates impulsive behavior, the researchers examined the synaptic changes in the brains of rats that were trained to control their impulsive response to a given signal.

The research found that behavioral training was effective with impulsive response in the rats, and showed changes in the prefrontal cortex of the brain. The research further suggests neuronal involvement behind impulsiveness that maybe be amenable to new therapies.

“A clear-cut case of an addiction is choosing the pleasure of the immediate sensation of the drug over the long-term damage and problems that it causes,” said Scott Hayton, a doctoral candidate in neuroscience at Queen’s University in Ontario and lead author of the study.

Understanding the neurological mechanism behind such impulses may aid in the development of new drugs to inhibit them, he concluded.

The findings were published in the August 25 2011 issue of the Journal of Neuroscience.

33 Million Americans Binge Drinking

In a new study presented by the CDC (Centers for Disease Control and Prevention), a reported 33 million Americans binge drink, which includes 25% of high school students and people aged between 18 to 34. The CDC defines binge drinking as consuming at least five alcohol drinks for men and four for women over a short period of time (i.e., a couple of hours).

The Director of the CDC, Dr. Frieden, said that “excessive alcohol use remains the third leading preventable cause of death in the United States and leads to a wide range of health and social problems” (Medical News Today). One of the authors of the study said that “almost 1 in 3 adults and 2 in 3 high school students who drink alcohol also binge drink.”

79,000 deaths each year in the U.S. are causes by excessive drinking. It increases the risks of car accidents, STDs, falls, fights, and unplanned pregnancies. Not only does binge drinking often lead to engaging in high-risk behavior, it increases the risk for alcohol dependence. In addition, it can have medium and long-term health consequences such as: depression, fetal alcohol disorders, heart disease, liver disease, cancer, and stroke.

“A Parents’ Guide” Helps Talk to Kids About Alcohol

When it comes to talking to kids about alcohol, parents often need all the help they can get. A recent Science Inside Alcohol Project funded by the National Institute on Alcohol Abuse and Alcoholism was produced by the American Association for the Advancement of Science (AAAS). Titled “Delaying the First Drink: A Parents’ Guide”, the project focuses on using science as a powerful tool for parents, teachers, and coaches to guide middle-school students away from drinking alcohol. The educational guide discusses research about the impact that alcohol has on a growing body and offers tips on how to talk to kids about drinking.

Studies have shown that kids who start drinking before the age of 15 are five times more likely to have alcohol-related problems as adults. So delaying the first drink could have a large impact of a kid’s life. The researchers for the project said that the focus is often on high school students who are at risk of combining drinking and driving, but fourth, fifth and sixth graders who drink are at risk of later consuming alcohol at higher levels. Drinking also contributes to poor school performance, early sexual activity, and other risky behavior.

When surveyed, a group of 143 seventh graders from several middle schools in the United States showed they knew very little about the science of alcohol, how it affects their bodies, and which of the body’s systems it effects. Nearly half of those questioned did not know how alcohol was made. The easy to read, informational booklet discusses the effects alcohol can have on the brain, especially a developing one. And it discusses the impact that alcohol has on the central nervous system, the digestive system, the heart, the liver and other organs.

The book is available online as a pdf at http://sciencenetlinks.com/media/filer/2011/09/29/delaydrinkingbook.pdf

Alcoholism-as-Disease: Idea Accepted but Not Sufferers

In 2010, the American Journal of Psychiatry found that despite more Americans now accepting the disease-model of alcohol dependency (one in which the origins are medical or genetic) than in the mid-1990s, they are still just as likely to retain a negative stigma or attitude toward those suffering with the illness of alcoholism.

Since the late 1990s, public advocates have promoted the view that substance abuse is rooted in neurobiology. Recently, researchers from Columbia University and Indiana University wanted to test if the public perception or attitude towards substance abuse, treatment and the people living with these disorders had also changed. They did so by comparing responses of American adults, questioned in 1996 and 2006, after listening to short vignettes describing individuals suffering from major depression, alcohol dependence, and more.

The survey revealed that there was a steady increase, across the board, between 1996 and 2006. It found more Americans to believe in a neurobiological root of alcohol dependence, to associate the disorder as a disease, and to support treatment. The percentage supporting treatment for major depression saw the largest increase.

However, despite the fact that these numbers increased, the negative stigmas surrounding alcohol dependency (one of the largest cited reasons for failure to receive treatment) failed to decrease. The research team recommended that addiction specialists, treatment providers, and advocates continue to find new ways to approach reducing stigma. One suggestion for future was to highlight a person’s abilities instead of just the disease.

 

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