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Addiction

Does Alcoholism Stigma Deter Seeking Help?

Albeit the availability of numerous programs that effectively treat alcohol dependencies, less than 25 percent of people who need help with alcoholism actually seek treatment. Individuals who often perceive a greater negative stigma surrounding substance abuse and dependencies avoid seeking treatment in fear of it confirming their inclusion into a stigmatized group. A study conducted by Columbia University found that of the people diagnosed with alcoholism, more than 60% said they would avoid seeking help if they believed they would be stigmatized if people knew. (ScienceDaily)

The study surveyed 34,653 members of the general population (6,309 had been been diagnosed with an alcohol-related disorder). The findings included that individuals diagnosed with an alcohol-related dependency- who perceived a negative stigma surrounding substance abuse – were 0.37 times less likely to seek treatment than those with similar alcohol-related dependencies who did not perceive a negative stigma surrounding substance abuse.  (Medical News Today)

Mike Sanders, founder of ExecuCare ARC, said that as a business professional he was affected by the perceived negative stigma prior to entering recovery for alcohol and prescription drug dependencies. As the owner of a company, he was attracted to the 10-day Neurotransmitter Restoration (NTR) because it was conducive to his circumstances. It was discreet, minimal withdrawal symptoms, eliminated cravings, restored clarity of mind, but most importantly, it broke the cycle of dependency and allowed him an entry point into the recovery process. “I can relate to negative stigma increasing the barrier of that entrance point,” he said.  Sanders opened ExecuCare in hopes of offering individuals the same opportunity NTR brought him.

In the study, other findings in the general population were: younger individuals perceived a less negative stigma surrounding substance abuse, but were less likely to seek treatment. Men perceived a more negative stigma than women but not by much (38.1% to 37.7%). The study also found that a perceived negative stigma towards alcohol dependency and necessary treatment was higher for those with lower personal income, lower education, and those previously married vs. those who had never been married. The study also showed that individuals with more chronic alcohol dependencies were more likely to seek treatment. (Medical News Today)

This is one of the few studies that focuses on the negative stigma surrounding alcohol dependencies and its relationship to underutilized treatment services. The researchers, who published the study’s findings in the November 2010 issue of the American Journal of Epidemiology, hope that it will encourage more effort in reducing the stigma surrounding alcohol-related dependencies, substance abuse, and necessary treatments.

A Molecular Switch for Memory and Addiction?

European scientists have identified a molecular switch that plays a crucial role in the establishing the formation of memory and addiction. (Science Daily).

Studies have found that learning and memory formation evolve from new connections made between neurons in the brain. Neuronal signals pass from one nerve cell to another via chemical compounds known as neurotransmitters. This signal is the basis for any learning process in the brain. It sets forth a sequence of cellular events that eventually alters neuronal connectivity. This results in the formation of memory. Drugs and alcohol can alter neuronal connectivity and create patterns of undesirable behavior.

The scientists have found that the molecular switch (an expression of the gene RyR2) is involved in a sustained release of calcium. This leads to neuronal plasticity (formation of new connections in the brain), specifically with the RyR2 protein being expressed in areas of the brain associated with cognition (and thus addiction). The expression of the RyR2 protein and the release of calcium was induced by the administration of nicotine to mice, thus suggesting that the induction of RyR2 plays a crucial role in the process of learning, memory formation, and development of addictive behaviors. When the scientists reduced the activation of RyR2, they found that it diminished behavior associated with learning, memory and addiction. This demonstrated that RyR2 is necessary for the long-term neuronal changes that lead to addiction.

It has been previously accepted that only the first step of neuronal plasticity involves calcium, which increases at the synapse (or site of neuronal connection). However, these scientists are challenging this notion by showing that in the second step, the calcium signaling will induce necessary gene expression in which a synthesis of proteins will lead to new or reinforced synaptic connectivity.

The study, which is published in EMBO Journal, further advances our understanding of the molecular processes behind memory and addiction. Many hope that it will lead to new strategies for treating drug and alcohol addiction and dealing with memory loss as a result of neurodegenerative diseases like Alzheimer’s.

Substance Abuse Risks Among Veterans

According to substance abuse data from the annual National Survey of Drug Use and Health (2002-2009), female veterans of the United States are much less likely than male veterans to binge drink, smoke cigarettes or use illicit drugs. However, both genders are equally likely to abuse prescription drugs (Center for Behavioral Health Statistics and Quality).

Since the 1970s, the number of women serving in the military has significantly increased with more women deployed to combat areas including combat support. Not only are women dealing with many of the same service-related stressors, they often encounter additional stress from being a female in a male-dominated profession. Despite this, 23 percent reported binge drinking in the past 30 days compared 43 percent of the male servicemen.

Previous studies have shown the increased risks for substance abuse and dependency among veterans compared to non-veterans, but few data analysis have compared men and women veterans. The finding that both genders are equally at-risk for prescription drug abuse is consistent with previous posts about the nation’s epidemic. As reported back in March, the military is trying to curb the amount of prescription drugs given to the troops after a study found that almost 3.8 million prescriptions for painkillers were written by military doctors for troops last year.

Understanding Impulse and Neurological Involvement: Addiction Insight

A recent study published in the Journal of Neuroscience found how a rat brain triggers and suppresses impulsive behavior. Canadian researchers hope that this will lead to new methods for diagnosing and treating addiction in humans.

How the brain deals with impulse control, or poor impulse control, is known to be involved in a number of complex mental health problems including addiction. In order to understand how the brain mediates impulsive behavior, the researchers examined the synaptic changes in the brains of rats that were trained to control their impulsive response to a given signal.

The research found that behavioral training was effective with impulsive response in the rats, and showed changes in the prefrontal cortex of the brain. The research further suggests neuronal involvement behind impulsiveness that maybe be amenable to new therapies.

“A clear-cut case of an addiction is choosing the pleasure of the immediate sensation of the drug over the long-term damage and problems that it causes,” said Scott Hayton, a doctoral candidate in neuroscience at Queen’s University in Ontario and lead author of the study.

Understanding the neurological mechanism behind such impulses may aid in the development of new drugs to inhibit them, he concluded.

The findings were published in the August 25 2011 issue of the Journal of Neuroscience.

Alcoholism-as-Disease: Idea Accepted but Not Sufferers

In 2010, the American Journal of Psychiatry found that despite more Americans now accepting the disease-model of alcohol dependency (one in which the origins are medical or genetic) than in the mid-1990s, they are still just as likely to retain a negative stigma or attitude toward those suffering with the illness of alcoholism.

Since the late 1990s, public advocates have promoted the view that substance abuse is rooted in neurobiology. Recently, researchers from Columbia University and Indiana University wanted to test if the public perception or attitude towards substance abuse, treatment and the people living with these disorders had also changed. They did so by comparing responses of American adults, questioned in 1996 and 2006, after listening to short vignettes describing individuals suffering from major depression, alcohol dependence, and more.

The survey revealed that there was a steady increase, across the board, between 1996 and 2006. It found more Americans to believe in a neurobiological root of alcohol dependence, to associate the disorder as a disease, and to support treatment. The percentage supporting treatment for major depression saw the largest increase.

However, despite the fact that these numbers increased, the negative stigmas surrounding alcohol dependency (one of the largest cited reasons for failure to receive treatment) failed to decrease. The research team recommended that addiction specialists, treatment providers, and advocates continue to find new ways to approach reducing stigma. One suggestion for future was to highlight a person’s abilities instead of just the disease.

 

Painkillers: Common Risk Factors for Addiction?

A Geisinger study, published in Addiction in 2010, found that patients with four common risk factors have a significantly higher risk of addiction to painkillers. Chronic pain patients who are 65 years or younger, have a history of depression, and use of psychiatric medication were common risk factors for the development of a substance abuse problem. A history of drug abuse further compounds the risk. Among the patients attributed with these risk factors, statistics show that one in four (26 percent) suffer with painkiller addiction.

The significance of these findings, as reiterated by the senior investigator of the study, is that most of this information can often easily and quickly be found in a patient’s medical record. “These findings suggest that patients with pre-existing risk factors are more likely to become addicted to painkillers, providing the foundation for further clinical evaluation,” said Joseph Boscarino, PhD, an epidemiologist and senior investigator at Geisinger’s Center for Health Research, cited online at HCP Live. “By assessing patients in chronic pain for these risk factors before prescribing painkillers, doctors will be better able to treat their patients’ pain without the potential for future drug addiction.”

Additionally, even without a history of chronic pain, patients with these risk factors may still be more likely to become addicted.

The study investigators accessed an electronic database to identify patients with back pain and related orthopedic conditions, who were prescribed painkillers for more than 90 days. The sample size was 705 patients. These patients were interviewed and had their DNA collected to be studied.

The team studied a gene located on chromosome 15 that was implicated in alcohol, cocaine, and cigarette smoking dependencies.  The data suggests there is an association of DNA variants in a gene cluster on this chromosome with opioid and nicotine addiction as well.

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