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Risk for Alcoholism and Obesity Linked

Researchers at Washington University School of Medicine have  found that those with a higher risk for alcoholism may also be at a higher risk for obesity. The study also found that this correlation between family history of alcoholism and obesity has become more pronounced over the years, which suggested that some of the risks are a function of the environment as well genetics.

The researchers analyzed data from two large alcoholism surveys from the past two decades inclusive of almost 80,000 participants. The study found that individuals with a family history of alcoholism had a greater risk for obesity. This proved even more true for women than men. In 2001 and 2002, women who had a family history of alcoholism were 49 percent more likely to be obese than those without alcoholism in their family history. The risk for obesity also seems to be growing. In the late 1970s in the U.S., 15 percent of the population was obese. By 2004 this percentage had nearly doubled (33 percent).

The research suggests that changes in the food we eat since the 70s and 80s may explain the connection between alcoholism and obesity. Today, many tend to consume higher calories and consist of a sugar, salt, fat combination that appeals to the reward center of the brain, the same brain areas that are effected by alcoholism. The greater availability of these foods may also contribute to the increase.

Alcohol abuse over-stimulates the reward center of the brain until it is unable to support itself with its own chemicals. This leads to anxiety, depression, and greater dependence on the substance. These high-caloric, hyper-palatable foods seem to stimulate the brain in the same way, leading to overconsumption and addiction. However, the researchers noted that not all alcoholics were obese or vice versa. One theory of explanation for obesity in individuals with a family history of alcoholism, is that many may avoid alcohol and turn to food instead, resulting in one addiction instead of another, because of the result the food has on their brain.

The researchers hope that their study will open up a dialogue among addiction therapists, treatment specialists, and those who study obesity. Understanding the correlation between alcoholism and obesity is important in determining methods of prevention and treatment and developing possible advancements in treatment.

Brain and Addiction Link Found in Gene

Researchers at Ohio State University believe they’ve found a genetic variant (characterized by one or both of two identified, tiny gene mutations) that is associated with a more than three times increase in susceptibility to severe cocaine abuse with the risk of fatal overdosing, compared to non-carriers of the genetic variant. (ScienceDaily)

This genetic variant was most common among white people with nearly one in five carrying the genetic variant. Among this group of people, one or both of the genetic variants were found in more than 40 percent of the autopsy brain samples from those known to abuse cocaine. This is compared to only 19 percent of those who lived drug-free and contained one or both of the genetic variants.

It was found that this genetic variant, one or both in combination, affect how dopamine functions in the brain. As we’ve discussed before, dopamine is a key neurotransmitter in the reward center of the brain, as well as numerous, regulatory functions of the central nervous system. Previous studies have shown that cocaine blocks dopamine’s reabsorption, leaving the chemical outside the brain cells and thus creates an artificial “feel-good” sensation.

This study found that in people who carry this genetic variant, the “function of a gene responsible for transmitting dopamine signals in the brain is altered” (Medical News Today). This led scientists to believe that this alteration can send neurotransmitters into a vicious cycle, including the development of cravings for an artificial substance, such as cocaine, that can maintain elevated levels of dopamine in the brain.

The study will soon be published in Neuropsychopharmacology. It has further opened the door to more questions about the involvement of the variant in initial use of the drug, level of cravings, and strength of the overall effect of the trait. It also suggests the need to explore how this variant could affect treatment for other psychiatric disorders involving dopamine.

Does Alcoholism Stigma Deter Seeking Help?

Albeit the availability of numerous programs that effectively treat alcohol dependencies, less than 25 percent of people who need help with alcoholism actually seek treatment. Individuals who often perceive a greater negative stigma surrounding substance abuse and dependencies avoid seeking treatment in fear of it confirming their inclusion into a stigmatized group. A study conducted by Columbia University found that of the people diagnosed with alcoholism, more than 60% said they would avoid seeking help if they believed they would be stigmatized if people knew. (ScienceDaily)

The study surveyed 34,653 members of the general population (6,309 had been been diagnosed with an alcohol-related disorder). The findings included that individuals diagnosed with an alcohol-related dependency- who perceived a negative stigma surrounding substance abuse – were 0.37 times less likely to seek treatment than those with similar alcohol-related dependencies who did not perceive a negative stigma surrounding substance abuse.  (Medical News Today)

Mike Sanders, founder of ExecuCare ARC, said that as a business professional he was affected by the perceived negative stigma prior to entering recovery for alcohol and prescription drug dependencies. As the owner of a company, he was attracted to the 10-day Neurotransmitter Restoration (NTR) because it was conducive to his circumstances. It was discreet, minimal withdrawal symptoms, eliminated cravings, restored clarity of mind, but most importantly, it broke the cycle of dependency and allowed him an entry point into the recovery process. “I can relate to negative stigma increasing the barrier of that entrance point,” he said.  Sanders opened ExecuCare in hopes of offering individuals the same opportunity NTR brought him.

In the study, other findings in the general population were: younger individuals perceived a less negative stigma surrounding substance abuse, but were less likely to seek treatment. Men perceived a more negative stigma than women but not by much (38.1% to 37.7%). The study also found that a perceived negative stigma towards alcohol dependency and necessary treatment was higher for those with lower personal income, lower education, and those previously married vs. those who had never been married. The study also showed that individuals with more chronic alcohol dependencies were more likely to seek treatment. (Medical News Today)

This is one of the few studies that focuses on the negative stigma surrounding alcohol dependencies and its relationship to underutilized treatment services. The researchers, who published the study’s findings in the November 2010 issue of the American Journal of Epidemiology, hope that it will encourage more effort in reducing the stigma surrounding alcohol-related dependencies, substance abuse, and necessary treatments.

Preparing for the Holidays: Avoiding Risk of Relapse

The holidays can be a difficult time for those in recovery. Aside from the many parties scheduled this month, there is often the added stressors of money, work, and family that accompany this time of year. With this said, the risk of relapse increases during the holiday season. This can be particularly worrisome for those who are new to recovery or whose loved ones are in recovery. Though there are many different ways that people relapse, we’ve highlighted some key ones below. Here are some signs to look for if you’re concerned about you or your loved one in recovery.

Becoming easily irritated or angered. At a high-stress time such as the holidays, you or a loved one may feel as if his or her sobriety is unstable and lash out for no apparent reason. Anger and irritability can also be masking feelings of fear, embarrassment or shame that may surround past substance abuse or current lifestyle of sobriety. Anger and irritability can also result from someone being unable or unwilling to seek help in getting a handle on the situation.

Difficulty handling life’s stresses. ‘Tis the season to be merry, right? But we all know what it feels like to be overwhelmed at times during the holidays. However, it becomes a concern for someone in recovery when daily stressors that a healthy person may take in stride, become catastrophic issues for those in recovery, especially those new in recovery. Clear out the calendar some this year, until you or your loved one has better strengthened coping strategies and regained the ability to deal with more intense situations.

Believing they will never relapse, no matter what! The holiday season is full of challenges for those in recovery. And often times, especially when someone is new to recovery, situations of temptation need to be avoided all together until someone’s coping strategies have been better developed. For example, someone who is not used to avoiding alcohol at parties may limit how many parties they go to until they are sure that they can still avoid alcohol while at the party. Overconfidence in how one can deal with such situations may be a sign of relapse risk, especially if someone is new to recovery. The truth is many need to avoid situations that involve drugs or alcohol no matter how staunch their initial convictions may be. This may mean missing the office holiday party this year. Think of things you and your loved one can do instead such as rent an old holiday movie and opt for hot coco and popcorn.

Lack or loss of commitment to recovery program. Recovery is not the same for everyone, and different things work for each individual. But a possible risk sign for relapsing is a sudden avoidance or disinterest in one’s recovery program. This could mean leaving a residential or outpatient program early, making excuses to avoid or quit private counseling, group counseling, or AA meetings.

Revisiting past behavior patterns. Similar to the one before, revisiting prior behavior patterns is a sign that you or a loved one is risking relapse. Undesirable behavior can be quickly relearned. And if a loved one begins hanging out with old drinking buddies or visiting places where his or her addiction was in full gear, the risk of relapse greatly increases.

If you recognize any of these signs in you or your loved one, don’t be afraid to speak up, reach out for help, or offer support. Remind yourself or your loved one of the consequences of relapse and what is at stake if the destructive behavior is continued. If you are dealing with a loved one in recovery, remember you are not the cause of or responsible for any relapse. Only your loved one can decide to stay in recovery. If you need help, be sure to reach out to an addiction specialist.

 

 

A Molecular Switch for Memory and Addiction?

European scientists have identified a molecular switch that plays a crucial role in the establishing the formation of memory and addiction. (Science Daily).

Studies have found that learning and memory formation evolve from new connections made between neurons in the brain. Neuronal signals pass from one nerve cell to another via chemical compounds known as neurotransmitters. This signal is the basis for any learning process in the brain. It sets forth a sequence of cellular events that eventually alters neuronal connectivity. This results in the formation of memory. Drugs and alcohol can alter neuronal connectivity and create patterns of undesirable behavior.

The scientists have found that the molecular switch (an expression of the gene RyR2) is involved in a sustained release of calcium. This leads to neuronal plasticity (formation of new connections in the brain), specifically with the RyR2 protein being expressed in areas of the brain associated with cognition (and thus addiction). The expression of the RyR2 protein and the release of calcium was induced by the administration of nicotine to mice, thus suggesting that the induction of RyR2 plays a crucial role in the process of learning, memory formation, and development of addictive behaviors. When the scientists reduced the activation of RyR2, they found that it diminished behavior associated with learning, memory and addiction. This demonstrated that RyR2 is necessary for the long-term neuronal changes that lead to addiction.

It has been previously accepted that only the first step of neuronal plasticity involves calcium, which increases at the synapse (or site of neuronal connection). However, these scientists are challenging this notion by showing that in the second step, the calcium signaling will induce necessary gene expression in which a synthesis of proteins will lead to new or reinforced synaptic connectivity.

The study, which is published in EMBO Journal, further advances our understanding of the molecular processes behind memory and addiction. Many hope that it will lead to new strategies for treating drug and alcohol addiction and dealing with memory loss as a result of neurodegenerative diseases like Alzheimer’s.

Substance Abuse Risks Among Veterans

According to substance abuse data from the annual National Survey of Drug Use and Health (2002-2009), female veterans of the United States are much less likely than male veterans to binge drink, smoke cigarettes or use illicit drugs. However, both genders are equally likely to abuse prescription drugs (Center for Behavioral Health Statistics and Quality).

Since the 1970s, the number of women serving in the military has significantly increased with more women deployed to combat areas including combat support. Not only are women dealing with many of the same service-related stressors, they often encounter additional stress from being a female in a male-dominated profession. Despite this, 23 percent reported binge drinking in the past 30 days compared 43 percent of the male servicemen.

Previous studies have shown the increased risks for substance abuse and dependency among veterans compared to non-veterans, but few data analysis have compared men and women veterans. The finding that both genders are equally at-risk for prescription drug abuse is consistent with previous posts about the nation’s epidemic. As reported back in March, the military is trying to curb the amount of prescription drugs given to the troops after a study found that almost 3.8 million prescriptions for painkillers were written by military doctors for troops last year.

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