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Newborn Neurons, a Key to Prevention?

A recent study by the University of Texas reports one of the most exciting neuroscience discoveries to date regarding prevention, as reported by the Scientific American, that addresses why some people are more prone to drug and alcohol addiction than others. What they found: there are new neurons born in the adult brain. This study, which was published in the Journal of Neuroscience, could hold key insight to prevention mechanisms and future models of studying addiction.

To show that a lack of neurogenesis, or birth of new neurons, can actually cause drug or alcohol addiction, the researchers blocked neurogenesis, the production of new neurons, in the hippocampus region of the brain of rats. They found the rats with fewer newborn neurons were more likely to become addicted and more likely to relapse after withdrawal or detox periods. The researches speculated that this may be the reason some people are more at risk when it comes to substance abuse. Based on the study’s results and evidence from other studies on addiction and the hippocampus, the research suggests that newborn neurons may inhibit the release of dopamine (a major chemical messenger of rewards signals in the brain). Also, people with fewer newborn neurons may get a bigger dopamine rush with the use of drugs or alcohol than others.

This is the strongest evidence to date in support of there being real biological reasons as to why some people might be more vulnerable to addiction than others. And it gives a better idea of the role of newborn neurons in the brain. Neuroscience research on addiction has mainly focused on the role of the reward centers in the brain, more increasingly, the hippocampus. In light of now knowing that new neurons are born in the hippocampus, recent research has sought to understand how adult neurogenesis is involved in addiction. The researchers concluded that there is a direct correlation between neurogenesis and addiction.

Ultimately this theory could lead to testing individuals for the presence of newborn neurons and may predict their predisposition or increased risk of addiction. This could prove to be an invaluable prevention and rehabilitation tool.

Prescription Drug Overdoses Up 65 Percent

Prescription Drug Overdoses Up 65 PercentAre prescription drug overdoses on the rise? According to a report released by Reuters Health on April 6, the number of annual U.S. hospital admissions due to poisoning by prescription opioids, sedatives and tranquilizers rose from about 43,000 to 71,000 between 1999 and 2006, respectively. This 65 percent increase is nearly double the amount observed in admissions due to the poisoning by other drugs and medications.

According to Dr. Jeffrey Coben of West Virginia University School of Medicine, most Americans see the headlines related to stars such as Heath Ledger, Michael Jackson, and Anna Nicole Smith and think that such tragedies pertain only to Hollywood. Coben and his colleagues who performed the study, said this assumption was to the contrary. The reality is research across the country is seeing “very significant increases in serious overdoses associated with prescription drugs.”

The most predominant prescription drugs associated with these overdoses are opioids, such as morphine, methadone, Oxycontin and the active ingredient in Percocet. These powerful narcotic painkillers have been found to be habit-forming. Also, sedatives or tranquilizers such as Valium, Xanax, and Ativan are the reason for the increase in admissions.

When asked why there has been such a rise in poisoning by prescription drugs, Coben and his team noted that there wasn’t any single cause. But rather a number of variations such as the increase in availability of powerful prescription drugs, as well as the attitude toward the use, or abuse, of prescription drugs tends to be different than ones toward using other drugs. This is especially true among young people, who say that prescription drugs are easy to obtain and they see them as less addictive and less dangerous than street drugs such as cocaine and heroin.

However, the rate of accidental, or unintentional, poising by opioids, sedatives and tranquilizers nearly doubled during the seven year study period. With unintentional poisoning now the second-leading cause of unintentional injury death in the United States.

The study, which was published in the April 2010 issue of the American Journal of Preventative Medicine, also found that urban, middle-aged women seem especially vulnerable to prescription drug overdoses. And that hospitalizations for methadone poisoning increased more than any other drug during the seven-year period.

Diets Worsen As Alcohol Intake Increases

According to a new study by researchers at the National Institute on Alcohol Abuse and Alcoholism Platter of unhealthy foods(NIAAA), National Cancer Institute (NCI), and the U.S. Department of Agriculture (USDA), people who drink more alcohol are also likely to eat less fruit and consume more calories from a combination of alcoholic beverages and foods high in unhealthy fats and added sugars. The study, which was published in the April issue of the Journal of the American Dietetic Association, examined more than 15,000 adults in the United States and found that increased alcoholic beverage consumption was associated with decreased quality in diet.

Heavy drinking and dietary factors have both independently been associated with cardiovascular disease, certain cancers, and other health problems. The study raises the question as to whether the combination of heavy drinking and poor diet might interact to further increase health risks.

“Our findings underscore the importance of moderation for individuals who choose to consume alcoholic beverages, and a greater awareness of healthy food choices among such individuals,” said one of the researchers. The 2005 U.S. Dietary Guidelines define moderate drinking as no more than one drink on any day for women and no more than two drinks on any day for men.

Study Finds Similar Biology in Compulsive Eating and Drug Addiction

A recent study conducted by The Scripps Research Institute found for the first time that the compulsion to overeat, often leading to obesity, affects the same biological mechanism, the brain’s pleasure circuitry, that causes drug addictions to substances like cocaine and heroin. The study was published in the March 28th issue of Nature of Neuroscience.

Overweight Man sits on couch with food, wrappers and beer cansAccording to Medical News Today, the study, which consisted of working with rats, confirmed what many obesity patients have been saying for years: that binging on junk food, like drug addiction, is very difficult to stop. The study showed “that as pleasure centers in the brain become less responsive, rats quickly develop compulsive overeating habits, eating increasing amounts of high-calorie, high-fat foods until they become obese.”

According to Medical News Today, this is the same progressively deteriorating chemical balance in reward brain circuits seen in rats that overconsume cocaine or heroin that is thought to lie behind the development of compulsive drug use.

“It presents the most thorough and compelling evidence that drug addiction and obesity are based on the same underlying neurobiological mechanisms,” said one of the researchers. “In the study, the animals completely lost control over their eating behavior, the primary hallmark of addiction.”

Those at risk seem to get caught in a cycle in which compulsive eating and substance abuse continue to hinder the recovery of either. Because there is evidence of the relationship between compulsive eating and drug addiction, hopefully the treatment for one will address the treatment of the other. Studies continue to show how addictive sugar and junk food are, especially for certain at-risk people. Individuals have reported that they often feel out of control when it comes to sugar and junk food. That they are unable to stop consuming these foods even after they become obese and have heath scares.

An Important Science Lesson Before Spring Break

Three young women on beach for spring break and drinkingWith Spring Break here and many girls tempted to take their first drink, it’s important to  explain to them why they can’t drink alcohol in the same way as boys. The Science Inside Alcohol Project of the American Association for the Advancement of Science suggests that girls be informed about the scientific research regarding the effects and dangers of alcohol consumption compared to boys. This is in hopes of delaying a girl’s first drink and alcohol abuse prevention.

A recent report from the Partnership for a Drug Free America found alcohol use among teens has risen 11 percent from 2008 to 2009. Studies find that teens are drinking younger and more frequently. In the 1960s, the Substance Abuse and Mental Health Services Administration reported seven percent of girls between the ages of 10 and 14 had their first drink. Today, 31 percent of girls try alcohol before entering high school. Studies have also shown that the younger a person is when they first start using alcohol increases their risk of developing substance abuse problems later in life.

According to The Science Inside Alcohol Project, here are some important scientific facts to share with teens:

– Girls have less water in their bodies than boys. Girls have a slightly higher proportion of fat to lean muscle tissue, concentrating alcohol more easily in their lower percentage of body water. This means they become intoxicated faster after drinking less alcohol.

– Girls have fewer enzymes to break alcohol down. Alcohol dehydrogenases are a group of seven enzymes that help break down alcohol so the body processes it. Girls have fewer of them, so it is not as easy for their bodies to metabolize the alcohol they drink.

– Girls are smaller and often weigh less than boys. When drinking the same amount as a boy, a girl will experience a quicker rise in her blood alcohol level, and she may stay intoxicated for a longer period of time. Girls who drink heavily can be at greater risk for alcohol poisoning because it takes less alcohol for them to get really sick.

– Girls often prefer sweeter, carbonated mixed drinks. Such drinks can speed up the absorption of alcohol into the bloodstream.

For more information on how to talk to a teen visit: http://www.aaas.org/programs/education/ScienceInside/alcohol/

The Prescription Drugs Epidemic Continues

A multitude of news stories broke this week that draw further attention to the increasing threat of prescription drugs epidemic. Abuse of prescription drugs, like substance abuse in general, shows no discrimination in the target demographic.

Person made out of prescription drugs and orally taking prescription drugsFirst, on the heels of last week’s blog about teen star, Corey Haim, investigators into his death found that he was using nearly twenty different doctors for prescription drugs. In his apartment they found prescription drugs such as Valium, Vicodin, Soma, and Haloperidol. He also had prescriptions written for OxyContin. Investigators now believe him to be linked to a prescription drug ring in California.

A recent study involving senior citizens (65 years or older) found that most of them, nearly 67%, take five or more types of prescription drugs and 21% take ten or more types of prescription drugs. This puts them at risk not only for abuse of certain prescription drugs, but also increases their risk of adverse effects and fatal interactions between the various drugs. This is awareness is crucial during a time when many U.S. cities are seeing a 70-80% increase (since 2000) in accidental overdoses due to prescription drugs.

This week at a pharmaceutical warehouse in Connecticut, police witnessed the most audacious example of a growing phenomenon when thieves stole $75 million worth of prescription drugs for resale on the black market.

CNN reported this week that 1 in 5 teens in grades 9 – 12 admitted abuse of prescription medication, especially xanax.

A recent article in Gastroenterology & Endoscopy News reported that physicians who are coping with prescription painkiller abuse are often flying under the radar. “[Misuse and abuse of prescription medications] is increasing, actually rather dramatically, in the population as a whole,” said Marv Seppala, MD, himself a recovering addict who was among the first physicians in the country to be certified by the American Board of Addiction Medicine. “Abuse of prescribed medications, specifically opioids, is now second to marijuana in terms of abuse,” he said. “There is also a remarkable increase in cases involving health care professionals.”

And lastly, some of the more alarming news regarding abuse of prescription drugs was released this week by the Pentagon about the Army. As reported by USA Today, the military is trying to curb the amount of prescription drugs given to the troops when a study found that military doctors wrote almost 3.8 million prescriptions for pain relief for troops last year. This was more than four times the 866,773 doses given in 2001. Military officials and analysts see the increase in use of pain medication as a result of the continuing toll on ground troops fighting in Iraq and Afghanistan. According to the results released this year, one in four soldiers admitted abusing prescription drugs, mostly pain medication, in the 12 months prior to the Pentagon survey in 2008.

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