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Scientists Link Stress Hormone to Alcohol Dependence

In a recent study soon to be published in Biological Psychiatry, scientists from The Scripps Research Institute found that the stress hormone, the corticotropin-releasing factor (CRF), may play an important role in the development and continuation of alcohol dependence.

stressed out woman drinking“It represents an important step in understanding how the brain changes when it moves from a normal to an alcohol-dependent state,” said Associate Professor Marisa Roberta, the lead researcher. “Our study explored what we call in the field ‘the dark side’ of alcohol addiction. That’s the compulsion to drink, not because it is pleasurable — which has been the focus of much previous research — but because it relieves the anxiety generated by abstinence and the stressful effects of withdrawal.”

According to Science Daily, CRF is a chemical involved with the body’s stress response. Originally, it was found only in the area of the brain known as the hypothalamus, but has more recently been found in other brain regions, including the pituitary, where it stimulates the secretion of corticotropin, and the amygdala, an area involved with the elevated anxiety, withdrawal, and excessive drinking associated with alcohol dependence. The results from these cellular studies showed that CRF increased the strength of inhibitory synapses (junctions between two nerve cells) in neurons in a manner similar to alcohol. This change occurred through the increased release of the neurotransmitter GABA, which plays an important role in regulating neuronal excitability.

The research team then administered the CRF antagonist R121919 for 23 days into the brains of rats that were exposed to conditions that would normally produce alcohol dependence. Remarkably, the behavior of the “alcohol-dependent” rats receiving one of the CRF antagonist R121919 mimicked their non-addicted counterparts. Instead of seeking out large amounts of alcohol like untreated alcohol-dependent rats, both the treated rats and their non-addicted brethren self-administered alcohol in only moderate amounts.

“This critical observation suggests that increased activation of CRF systems mediates the excessive drinking associated with development of dependence,” said Roberto. She also noted that an intriguing aspect of the study is that it provides a possible physiological link between stress-related behaviors, emotional disorders (i.e. stress disorders, anxiety, depression), and the development of alcohol dependence.

New Club Drug Gains Popularity in U.K.

A currently legal stimulant known as mephedrone has gained recent popularity among club-goers according to Britain’s National Addiction Center. On January 14, The BBC reported that mephedrone was the fourth most popular drug cited by readers of a popular dance magazine. Surprisingly, one in three readers polled had used the new club drug in the last month.

MephedroneMephedrone — a stimulant that is currently legal in both the U.K. and the U.S. — has gained recent and surprising popularity among club-goers in the U.K., according to Britain’s National Addiction Center.

“It’s come from nowhere to become very popular,” said one of the researchers. “For a drug that’s been around for a relatively short amount of time, mephedrone has certainly made a big impact on the dance drug scene. [And] at the moment we just don’t have enough research to know what it does to people in the short term and long term. ”

The drug is often sold online through dozens of websites as “plant food” and “not for human consumption,” although its use as a fertilizer is unknown. Though little is known about its effects, experts believe mephedrone to be a different version of classical amphetamines and carry similar problems associated with such use.

The drug is also known as meph, 4-MMC, MCAT, Drone, Meow or Bubbles. It is a powder that can be taken in pill form, snorted, mixed with liquid or even injected.

New Prevention Tactics Needed for Baby Boomers

A recent report, “Illicit Drug Use Among Older Adults,” from the Substance Abuse and Mental Health Services Administration (SAMHSA) warned that the need for treatment services among older Americans may double in the next decade. Meaning there are new prevention tactics needed to address the rise in drug abuse among baby boomers.

Pill in baby boomer's handThe report found that an estimated 4.3 million Americans age 50 and older used illicit drugs during the past year, a figure that experts say “is on the rise and reflective of lifelong drug use by aging Baby Boomers.” Marijuana use was more prevalent than nonmedical use of prescription drugs for adults aged 50-59, but among those aged 65 or older, abuse of prescription drugs was more common.

Researchers hoped that the report will raise concern for the changes in addiction prevention and treatment that may be necessary to address the growing problem of older generations of substance abusers. “This new data has profound implications for the health and well-being of older adults who continue to abuse substances,” said a SAMHSA Administrator. “These findings highlight the need for prevention programs for all ages as well as to establish improved screening and appropriate referral to treatment as part of routine health care services.”

Common signs and symptoms of drug abuse (HelpGuide.org)

  • You’re neglecting your responsibilities at school, work, or home (e.g. flunking classes, skipping work, neglecting your children) because of your drug use.
  • You’re using drugs under dangerous conditions or taking risks while high, such as driving while on drugs, using dirty needles, or having unprotected sex.
  • Your drug use is getting you into legal trouble, such as arrests for disorderly conduct, driving under the influence, or stealing to support a drug habit.
  • Your drug use is causing problems in your relationships, such as fights with your partner or family members, an unhappy boss, or the loss of old friends.
  • You’ve built up a drug tolerance. You need to use more of the drug to experience the same effects you used to attain with smaller amounts.
  • You take drugs to avoid or relieve withdrawal symptoms. If you go too long without drugs, you experience symptoms such as nausea, restlessness, insomnia, depression, sweating, shaking, and anxiety.
  • You’ve lost control over your drug use. You often do drugs or use more than you planned, even though you told yourself you wouldn’t. You may want to stop using, but you feel powerless.
  • Your life revolves around drug use. You spend a lot of time using and thinking about drugs, figuring out how to get them, and recovering from the drug’s effects.
  • You’ve abandoned activities you used to enjoy, such as hobbies, sports, and socializing, because of your drug use.
  • You continue to use drugs, despite knowing it’s hurting you. It’s causing major problems in your life—blackouts, infections, mood swings, depression, paranoia—but you use anyway.

Cravings Still a Problem with Cocaine Vaccine

A study recently reported by the Washington Post found the new cocaine vaccine, TA-CD, does nothing to address the brain’s cravings for the drug. As a result, users were more likely to dangerously ingest larger quantities of cocaine in attempt to satisfy the cravings and overcome the vaccine’s effect.

cocaine vaccineThe vaccine TA-CD is a series of shots that ultimately change the body’s chemistry. Working like most vaccines, TA-CD causes the body’s immune system to produce antibodies that stay active for eight to ten weeks. These antibodies bind to cocaine molecules in the blood, making them too large to pass into the brain, thus preventing any possible artificial high.

The study found that immunization did not achieve complete abstinence from cocaine use; however, previous research has shown a reduction in use and improvement in abuser’s social function thus rendering the vaccine to be therapeutically meaningful by some. In the recent study, according to the Washington Post, researchers found that subjects who were administered the drug stayed off cocaine more than half the time once they had built up a high level of antibodies and immunity to the drug, compared to 23 percent of those who built up fewer antibodies and less immunity. About one in four vaccine recipients failed to develop sufficient antibodies to block the drug’s effects, and scientists were unsure why this was the case.

After being administered the vaccine, abusers reported that doing cocaine became a very disappointing experience; however, their cravings to use the drugs were not reduced. Though this vaccine is being highlighted as “promising” by some scientists, and though none of the study’s participants overdosed, the situation posed by the vaccine makes overdosing a possible, serious problem if used as a treatment option. The idea of developing medication that “blocks addiction” has long been appealing, but the inability to get high combined with the presence of intense cravings could lead to lethal situations if relapse were to occur.

Women and Alcohol: The Scary Reality

In recent news, women and alcohol have become a scary reality. It has become more apparent that the number of women abusing alcohol is a pressing and, at times, life-threatening issue. According to the FBI, more women are being arrested nationally for driving while under the influence of drugs or alcohol (up 28% from 1998), and about 5.3 million women in the U.S. threaten their health and safety with the use of alcohol.

Women and alcohol is not always a good mix. Three women and alcohol at lunchMany women think that extra cocktail when out with the ladies or another glass of wine with dinner won’t hurt. However, surprisingly, there is a fine line between moderate and excessive drinking. According to U.S. Dietary Guidelines, women should not have more than one alcoholic drink a day (12 ounces of beer, 5 ounces of wine or 1.5 ounces of 80-proof distilled spirits).

But more so than quantifying how much is too much, it’s important to take a look at why this drink limit is crucial to women’s health. Although the drink limit is greater for men, and men are two to three times more likely to abuse alcohol then women, women who abuse alcohol are significantly more likely to have medical problems and develop them earlier in their substance abuse than men. For example, if a woman drinks the same amount as a man, she’s more likely, according to the University of North Dakota School of Medicine and Health Sciences, to develop liver-related disease.

Some of this might be due to women’s bodies having a lower water content than men. Their bodies also tend to break down acetaldehyde (a toxic byproduct of alcohol) more slowly so it stays in the liver longer. Scientists have also found that women’s higher levels of estrogen make some liver cells more sensitive to alcohol’s toxic effect. According to British Million Woman Study, as little as one alcoholic drink a day may increase women’s risk for cancers of the mouth, throat, esophagus and rectum. Women drinkers are also more likely to get stomach ulcers as a result of drinking, and for some, risk for breast cancer increases. Though the resveratrol in red wine has shown to have heart healthy benefits, drink more than the recommended glass per day and those benefits are reversed. In fact, heavy drinking is the leading cause of cardiovascular disease.

Understanding how these risks might outweigh some of the benefits is important even for light to moderate drinkers. And for those who worry they might be drinking too much, take the following quiz at LifeScript.com.

Here are some warning signs of possible alcohol abuse:

  • Can never stick to “just one” drink.
  • Regularly drink more than you intended to.
  • Feel guilty or ashamed about your drinking.
  • Lie to others or attempt to hide your drinking habits.
  • Have friends or family who have express their concern about your drinking habits.
  • Need to drink in order to relax or feel better.
  • Ever “black out” or forget what you did while you were drinking.
  • Repeatedly neglect responsibilities at home, work, or school due to alcohol use.
  • Continue to drink despite relationship problems it’s causing.
  • Drink in physically dangerous situations such as driving or mixing with prescription drugs.
  • Repeated legal problems due to alcohol.
  • Experience cravings, tolerance, or withdrawal symptoms.

New Year Resolutions Inspiration

It’s that time of yJanuary First Calendar, apple and measuring tape for New Year's Resolutionsear again: New Year Resolutions. Whether it’s that new gadget you splurge on for husband or eating one too many holiday treats, December is a time to be merry and indulge. With the holidays in full gear, we know we have one last ooh-rah before the diet books come out and we attempt to tackle our New Year’s resolutions. However, for those families who suffer from addiction, the holidays and especially New Year’s can be a daunting time that is always marked by the failure to change. Kevin Sanders, co-founder of ExecuCare Addiction Recovery Center, knows first hand these challenges. Her husband, Mike Sanders, struggled with a long-time addiction to alcohol and more recently OxyContin and Xanax before seeking treatment in January 2005 with her encouragement.

“He’s a successful business man, a community leader, and a loving husband and father, but addiction shows no discrimination,” Kevin Sanders said of Mike, father of three and investment firm owner. “As small business owners, we didn’t have thirty, sixty or ninety days for him to spend in rehabilitation. NTR was this miracle we happened upon.”

Neurotransmitter Restoration (NTR) is a medical nutritional therapy. The IV infusions of amino acids “bathe” cells giving them continuous exposure to an optimized nutrient environment and speed up the healing process. As a result, NTR helps individuals discontinue the use of drugs or alcohol, while repairing the damage done to the brain as a result of chronic use without using drug replacement therapy. Because the body is getting what it needs naturally, NTR safely detoxifies while minimizing post acute withdrawal symptoms, significantly reducing cravings, anxiety and depression, normalizing stress levels, and restoring a sense of well-being and clarity of mind. Kevin noticed Mike’s sense of well-being improved immediately. “He was calmer, more patient,” she said.

Almost five years later, Mike’s investment firm continues to thrive; he is alcohol and drug free, and they are committed to making this unique treatment more broadly available to others. They opened the doors to ExecuCare Addiction Recovery Center in Norcross, Ga., in September 2006.

“Most addiction treatments solely focus on the psychological and social aspects of addiction, ExecuCare ARC is one of the few recovery centers to work on the physical form of the disease of addiction by restoring normal brain function,” Kevin further explained. “We attack addiction at its physical root.”

ExecuCare ARC is one of the few clinics in the United States to offer the Neurotransmitter Restoration, a revolutionary approach to addressing the physical form of addiction, and the Sanders plan to open more in the near future. ExecuCare ARC operates on the belief that when NTR protocols precede traditional therapy treatments, individuals experience much higher success rates in long-term recovery. By addressing the physical form of the disease first with NTR, an individual is better prepared to make the psychological, behavioral, social and spiritual changes necessary in the next phases of recovery. While at ExecuCare ARC, therapists and addiction specialists design and implement customized intense outpatient programs that allow patients to continue their recovery.

“I truly believe in the strength and power of family, and its ability to overcome obstacles together,” Kevin said when discussing how she and the three kids have helped Mike with the opening of ExecuCare ARC. “I hope that ExecuCare ARC brings the same hope and healing to other families as it has brought to mine.”

Happy New Year! Here’s to 2013 bringing more inspiring stories of recovery!

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